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Cannabinoids ameliorate pain and reduce disease pathology in cerulein-induced acute pancreatitis

posted by cbdiscov 13 hours ago

Gastroenterology. 2007 May; 132(5):1968-78.
Michalski CW, Laukert T, Sauliunaite D, Pacher P, Bergmann F, Agarwal N, Su Y, Giese T, Giese NA, Bátkai S, Friess H, Kuner R

Discuss | category: GI / Hepatology | tags: Acute Disease Animals Biopsy Caerulein Cannabinoids Endocannabinoids Female Gene Expression Regulation Humans Male Mice Mice Inbred C57BL Neuroprotective Agents Pain Pancreas Pancreatitis Receptor Cannabinoid CB1 Receptor Cannabinoid CB2 Tetrahydrocannabinol all

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Inhibition of poly(adenosine diphosphate-ribose) polymerase by the active form of vitamin D

posted by cbdiscov 13 hours ago

Int J Mol Med. 2007 Jun; 19(6):947-52.
Mabley JG, Wallace R, Pacher P, Murphy K, Szabó C

Discuss | category: Drug Discovery | tags: Animals Calcitriol Cells Cultured Dose-Response Relationship Drug Humans Keratinocytes Macrophages Mice Poly(ADP-ribose) Polymerases Vitamin D all

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A2A adenosine receptors and C/EBPbeta are crucially required for IL-10 production by macrophages exposed to Escherichia coli

posted by cbdiscov 13 hours ago

Blood. 2007 Oct 1; 110(7):2685-95.
Csóka B, Németh ZH, Virág L, Gergely P, Leibovich SJ, Pacher P, Sun CX, Blackburn MR, Vizi ES, Deitch EA, Haskó G

Discuss | category: Immunology | tags: 5' Flanking Region Adenosine Animals CCAAT-Enhancer-Binding Protein-beta Cells Cultured Enzyme Activation Escherichia coli Interleukin-10 Macrophages Male Mice Myeloid Differentiation Factor 88 Promoter Regions (Genetics) RNA Messenger Receptor Adenosine A2A TNF Receptor-Associated Factor 6 Toll-Like Receptor 4 p38 Mitogen-Activated Protein Kinases all

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Homocysteine induces cell death in H9C2 cardiomyocytes through the generation of peroxynitrite

posted by cbdiscov 13 hours ago

Biochem Biophys Res Commun. 2007 Aug 3; 359(3):445-50.
Levrand S, Pacher P, Pesse B, Rolli J, Feihl F, Waeber B, Liaudet L

Discuss | category: Cardiology | tags: Animals Apoptosis Caspase 3 Catalysis Cells Cultured Cytoprotection Extracellular Signal-Regulated MAP Kinases Homocystine JNK Mitogen-Activated Protein Kinases L-Lactate Dehydrogenase Metalloporphyrins Myocytes Cardiac Necrosis Peroxynitrous Acid Phosphorylation Poly(ADP-ribose) Polymerases Rats all

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Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors

posted by cbdiscov 13 hours ago

Nat Neurosci. 2007 Jul; 10(7):870-9.
Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, Brenner GJ, Rubino T, Michalski CW, Marsicano G, Monory K, Mackie K, Marian C, Batkai S, Parolaro D, Fischer MJ, Reeh P, Kunos G, Kress M, Lutz B, Woolf CJ, Ku

Discuss | category: Neuroscience | tags: Alleles Analgesia Animals Cannabinoids Central Nervous System DNA Primers Electrophysiology Endocannabinoids Ganglia Spinal Mice Mice Inbred C57BL Mice Knockout Nerve Fibers Unmyelinated Neurons Afferent Nociceptors Peripheral Nervous System Peripheral Nervous System Diseases Receptor Cannabinoid CB1 all

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The adenosine A2A receptor agonist CGS 21680 fails to ameliorate the course of dextran sulphate-induced colitis in mice

posted by cbdiscov 13 hours ago

Inflamm Res. 2007 May; 56(5):204-9.
Selmeczy Z, Csóka B, Pacher P, Vizi ES, Haskó G

Discuss | category: GI / Hepatology | tags: Acetylcholine Adenosine Animals Antihypertensive Agents Chemokine CCL3 Chemokine CCL4 Chemokine CXCL2 Chemokines Colitis Dextran Sulfate Gene Expression Regulation Interleukin-1beta Macrophage Inflammatory Proteins Male Mice Mice Inbred Strains Muscle Smooth Phenethylamines Receptor Adenosine A2A all

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Role of nonsynaptic communication in regulating the immune response

posted by cbdiscov 13 hours ago

Neurochem Int. 2008 Jan; 52(1-2):52-9.
Selmeczy Z, Vizi ES, Csóka B, Pacher P, Haskó G

Discuss | category: Immunology | tags: Animals Cell Communication Humans Immune System Receptors Adrenergic Receptors Purinergic P1 Synapses all

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Cannabinoid-2 receptor agonist HU-308 protects against hepatic ischemia/reperfusion injury by attenuating oxidative stress, inflammatory response, and apoptosis

posted by cbdiscov 13 hours ago

J Leukoc Biol. 2007 Dec; 82(6):1382-9.
Rajesh M, Pan H, Mukhopadhyay P, Bátkai S, Osei-Hyiaman D, Haskó G, Liaudet L, Gao B, Pacher P

Discuss | category: GI / Hepatology | tags: Alanine Transaminase Animals Apoptosis Cannabinoids Cell Adhesion Chemokines Endothelial Cells Humans Inflammation Inflammation Mediators Intercellular Adhesion Molecule-1 Ischemia L-Lactate Dehydrogenase Leukocytes Lipid Peroxidation Liver Mice Oxidative Stress Peroxidase Receptors Cannabinoid Reperfusion Injury Tumor Necrosis Factor-alpha Vascular Cell Adhesion Molecule-1 all

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CB2-receptor stimulation attenuates TNF-alpha-induced human endothelial cell activation, transendothelial migration of monocytes, and monocyte-endothelial adhesion

posted by cbdiscov 13 hours ago

Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2210-8.
Rajesh M, Mukhopadhyay P, Bátkai S, Haskó G, Liaudet L, Huffman JW, Csiszar A, Ungvari Z, Mackie K, Chatterjee S, Pacher P

Discuss | category: Cardiology | tags: Animals Anti-Inflammatory Agents Aorta Cannabinoids Cells Cultured Chemokine CCL2 Coronary Vessels Disease Models Animal Dose-Response Relationship Drug Endothelial Cells Humans Inflammation Intercellular Adhesion Molecule-1 Leukocyte Rolling Lipopolysaccharides Male Mice Mice Inbred C57BL Monocytes NF-kappa B RNA Messenger Receptor Cannabinoid CB1 Receptor Cannabinoid CB2 Signal Transduction Tumor Necrosis Factor-alpha Vascular Cell Adhesion Molecule-1 rhoA GTP-Binding Protein all

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Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy

posted by cbdiscov 13 hours ago

Nat Protoc. 2007; 2(9):2295-301.
Mukhopadhyay P, Rajesh M, Haskó G, Hawkins BJ, Madesh M, Pacher P

Discuss | category: Mol / Cell Biology | tags: Annexin A5 Apoptosis Biological Markers Cell Line Flow Cytometry Fluorescent Dyes Humans Microscopy Confocal Mitochondria Organic Chemicals Phenanthridines Superoxides all

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