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JAK2 gets histone H3 rolling.Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
Activation of JAK2 is implicated in normal hematopoiesis as well as oncogenic transformation. A paper in the recent issue of Nature demonstrates that phosphorylation of histone H3 by JAK2 releases the transcriptional repressor HP1alpha from chromatin, resulting in gene transcription.
PMID: 19878867 [PubMed - indexed for MEDLINE]
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